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Localized nanodelivery platforms can improve sitespecific targeting and reduce systemic exposure, yet their longterm safety, pharmacokinetics, release profiles and therapeutic durability require rigorous validation in relevant largeanimal models and clinical trials

Consequently, they are better suited for in vivo administration in humans than wholly animal antibodies, especially when repeated or long-term administration is necessary

A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities

PsathakisKMermigkisDPapatheodorouGLoukidesSPanagouPPolychronopoulosVet al

Therefore, hydrophilic blocks should be added to the design of polymer micelles to avoid polymer adsorption by plasma proteins or removal from the body by complement activation (Hwang et al., 2020)