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Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2

The drug is registered by the Ministry of Health, Labour and Social Welfare of Georgia (registration certificate No.003658) and approved for use in T2DM either independently or in combination with other hypoglycemic agents (Kemertelidze et al., 2012)

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Lide, Ed., CRC Press, Inc., Boca Raton, FL Fujimura M, Usuki F, Sawada M, Takashima A (2009) Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain

The beneficial effects of flavonoid CD38 inhibitors were reported in animal models of obesity, heart ischemia, kidney injury, viral infection, and cancer [71-77]