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About 1-2% of people develop sensitivity

85 Mattioni MarchettiV.KraftovaL.FinianosM.SourenianT.HrabakJ.BitarI

Notably, 5-HT itself functions as a key immunomodulatory molecule: in the intestine, 5-HT secreted by EC cells tends to exert pro-inflammatory effects, in contrast to the anti-inflammatory properties of neuron-synthesized 5-HT (293)