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Immunobiol 218:14521467 Feigin V, GBD (2017) Causes of death collaborators: Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 19802017: a systematic analysis for the Global Burden of Disease Study

The alignment analysis of 87 GPX protein homologs also confirmed this claim, demonstrating the presence of more conserved residues in the main sites of the active enzyme (Supplementary Figure S2)

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Moreover, an enriched subgroup analysis of the URICOI-ICTUS trial revealed that UA treatment was safe, well-tolerated, and provided substantial benefits of UA in terms of the primary outcome(modified Rankin Scale score at day 90)