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and preparing L-carnitine of Formula 6 from the (R)-4-chloro-3-hydroxy butyric acid alkyl ester of Formula 4 according to the known method

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Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival

Given that arginine deprivation therapies (e.g., ADI-PEG20) have entered clinical trials for various arginine auxotrophic tumors, future research needs to define how to precisely trigger ferroptosis in tumor cells via arginine metabolic pathways without damaging immune cell function [114]

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