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While the most toxic antiretroviral drugs (e.g., Efavirenz) are slowly being taken out of the market, more research is still needed to fully discriminate ART toxicity and its contribution to comorbidities observed in HIV-positive patients, especially in the context of aging, which alters both drug kinetics and susceptibility of the host to ART-induced side effects

doi: 10.1016/j.tox.2022.153152 47 YangJXueJHuWZhangLXuRWuSet al

343 According to a 2020 systematic review and meta-analysis that included 60 randomized controlled trials with a total of 4,129 patients, omega-3 fatty acid supplementation appeared to decrease the incidence of cardiovascular death by 55% in CKD patients on hemodialysis, though it did not appear to reduce mortality overall

Finally, to assess a functional indicator of oxidative damage and mitochondrial reactive oxygen species production, the activity of aconitase, a redox-sensitive enzyme in the tricarboxylic acid cycle, was measured

PLS-DA, partial least-squares discriminant analysis