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If you have a medical condition where you are unable to absorb sufficient B12 from your diet, you will need to get a shot every week/month to stay healthy.

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According to Venuka Wick, MD, an assistant clinical professor in the department of family medicine at University of Washington Medicine in Seattle, its best to only take supplements under the guidance of a healthcare provider, as too much of certain vitamins can be harmful

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Howden R, Anderson CR, Goldsbrough PB, Cobbett CS (1995) A cadmium-sensitive, glutathione-deficient mutant of Arabidopsis thaliana