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Much of the current evidence for protein persulfidation comes from semi-quantitative and qualitative chemoselective labelling approaches to identify the cysteine residue modified on the protein 24,25,26,27

Please see the online posting for VANFLYTA for the applicant's complete statements regarding the substantial clinical improvement criterion and the supporting evidence provided

Best Available Data We refer readers to section I.E

These combined effects highlight VD as a multifaceted modulator of inflammation, oxidative stress, and cell death in MAFLD (Figure 2B) (Miao et al., 2025)

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