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Secondary BAs play a role in the modulation of immune system activity through BAs receptors, such as Takeda G-protein-coupled BAs receptor-1 (TGR5), farnesoid X receptor (FXR), pregnane X receptor (PXR), retinoid-related orphan receptor-t (RORyt), and Vitamin D receptor (VDR) [25]

Abstract Evidence is emerging that dysregulation of circulating concentrations of homocysteine, an important intermediate in folate and vitamin B12 metabolism, is associated with autism spectrum disorder (ASD), but comprehensive assessments and correlations with disease characteristics have not been reported

Thevaranjan et al., 2017)

[10] PDC links glycolysis to the citric acid cycle, catalyzing the irreversible oxidative decarboxylation of pyruvate to acetyl-CoA, with carbon dioxide (CO 2 ) release and electron transfer to NAD +

It has been postulated that glutathione can counter this oxidative stress and help alleviate the cytokine storm associated with COVID-19 [Table 2].[] GLUTATHIONE SUPPLEMENTATION IN PREGNANCY AND LACTATION As per the data available, there is no conclusive evidence of use of glutathione in pregnancy and lactation