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*Correspondence: Azhar Hussain [email protected] Wang [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Nutrition and Food Science Technology, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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In the classical pathway involving Factor Associated Suicide/Fas ligand (Fas/FasL) signaling, the Fas receptor interacts with FasL, which is predominantly secreted by activated T cells, natural killer (NK) cells, and specific malignant tumor cells, via its extracellular domain