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As a specific type of Prolotherapy called Prolozone, ozone can be injected into diseased joints

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D-carnitine without bioactivities in people, however, has adverse biological effects via suppressing the carnitine acetyltransferase (23), with supplementation of D-carnitine inducing oxidative stress, liver inflammation, and apoptosis in animal studies (24), causing secondary carnitine deficiency, and therefore, almost no human studies of D-carnitine have been conducted (21)