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However, simple crossing of the SOD1G93A mice with mice overexpressing EAAT2 (to about a double of the normal level) resulted in an ALS model where the appearance of ALS signs and the onset of the motor neuron loss were only marginally delayed, with no effect on the final outcome [392]

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Macroautophagy starts with a precursor structure, known as the phagophore, that eventually transforms into an autophagosome