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so, for cases where some samples were below detection limit, our reported averaged values are an upper bound to the true average value

This result supports the concept that there is no inherent increase of ROS upon ATMi when cells are maintained at 3% O 2 , but there is a defect in maintaining GSH levels

It has been suggested that riboflavin has a direct free radical scavenging activity through conversion from reduced (dihydroriboflavin) to oxidised form (Reference Toyosaki49)

The antibodies used are listed in Appendix Table S1

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