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The identified protein was filtered using 1% false discovery rate and at least two peptides per protein as limiting parameters

After internalisation, when pH increases above 6.5, the amino groups of chitosan become positively charged and chitosan precipitates, inducing increased intracellular drug accumulation

It activated the Nrf-2/ARE signaling pathway, this subsequently decreased the elevated production of ROS and MDA, enhanced the expression of SOD and GSH, and ultimately resulted in a reduction of oxidative stress levels

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