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A study in germ-free mice versus mice colonized with gut microbiota showed that the gut microbiota influences the hosts development of hypertensive organ damage, with TMAO and other microbial metabolites such as short-chain fatty acids (SCFAs) contributing to the phenotype (Avery et al., 2023)

Acylcarnitine also plays a role in the pathological development of nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) by affecting the DNA methylation pattern of macrophages and directing macrophage function in a proinflammatory direction [45]

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The protein carnitine-acylcarnitine translocase, also known as solute carrier family 25 member 20 (SLC25A20), is an important component of the inner mitochondrial membrane and is essential for the transport of acylcarnitine into the mitochondrial matrix (4)