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doi: 10.1016/j.ncl.2021.06.002 178 OaklanderA

Improving delivery efficiency may require pediatric-focused innovations such as lung-targeted nanocarriers, stress-responsive promoters, or optimized formulations of natural products suitable for children

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In yet another embodiment, a controlled release system can be placed in proximity of the therapeutic target, i.e., the brain, thus requiring only a fraction of the systemic dose (see, e.g., Goodson, in Medical Applications of Controlled Release, supra, vol

10.1016/j.jphs.2021.03.001 53 MostafaM.DisoukyA.LazarovO