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The clinical relevance of this adjunctive therapy in humans remains to be established

According to the meta-analysis, the dose that was useful for significantly improving the level of plasma lactate was 2 g/dL for 12 weeks

This interaction is important for driving T cell polarization towards particular subsets, such as the T helper cells, which then further differentiate into Th1, Th2, Th17, or regulatory T cells (Tregs) (114)

For instance, iridoids like geniposidic acid and asperuloside, phenylpropanoids like chlorogenic acid, and lignans have all been documented to inhibit p38 MAPK phosphorylation in various mammalian models of inflammation and stress (5355)

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