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PMID: 38452838 Cancer Cell Int ROR inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity

Can probiotics trigger die-off

M.AgbayaniG.SimardB.DudaniR.HarrisonB

elegans and mice showed that EGCG's transient inhibition of Complex I in the electron transport chain triggered an adaptive stress response (mitohormesis) that ultimately restored ATP levels, reduced reactive oxygen species below baseline, and significantly extended lifespan and physical fitness

Enzymes supporting phase 2 detoxification reactions, such as those involved in the biosynthesis of glutathione (e.g., -glutamylcysteine synthetase or GCS) and its conjugation to substrates (e.g., glutathione S -transferases or GSTs), are rapidly induced following exposure to stressful stimuli