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Inhibition of miR-29b-3p or miR-378g upregulates NNMT expression and promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), whereas overexpression of miR-29b-3p or miR-378g downregulates NNMT expression and inhibits osteogenic differentiation of BMSCs

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Combined NNMT inhibitor treatment with reduced-calorie diet achieved 6.3 g cumulative weight loss versus 2.9 g with diet alone, and fat mass reduction was ten-fold greater with treatment (~29.3%) compared to diet switch alone (2.9%), while restoring fatty liver profiles to lean-control levels (Sampson et al., 2021)

There is no discomfort after the procedure