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& Fiehn, O

8-hydroxy-2 -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis

10.1007/s10549-018-4753-7 36 FraserJ

SochaPGroteVGruszfeldDJanasRDemmelmairHClosa-MonasteroloRet al

In vivo , findings demonstrate that the overexpression of indoleamine 2,3-dioxygenase (IDO) restricts ATP production in CD8+ cells, whilst in vitro studies indicate this effect is mediated by reduced activity of electron transport chain complex I, which accounts for the decreased ATP production observed in infiltrating T cells (Liu et al., 2009)