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furthermore, 60-70% of patients stop treatment within the first 12 months

As mitochondria are sensitive to stress mediators, including cortisol in humans and corticosterone in mice, and mitochondrial respiration is a primary source of cellular energy, it is postulated that allostasis involves metabolic and mitochondrial mechanisms 37,39,40,41,42,43

Cellular ROS detection assay Following spheroids treatment with different Vit-C doses for 72 h, the cellular ROS was determined by performing the ROS-GLO H 2 O 2 ASSAY (PROYY-G8820, Promega, USA) according to the protocol from the manufacturer

Methods: Rats and H9C2 cells were used to perform MIRI model

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