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In contrast, an overdose of APAP causes hepatotoxicity by saturating the sulfation pathway and generating NAPQI that leads to a robust reaction between NAPQI and hepatic glutathione stores, which subsequently depletes glutathione (Xie et al., 2015)

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Two predicted drugs (gemcitabine and cladribine) and one NO-based drug (diphenyleneiodonium) have a reported median IC 50 below 0.4 M in melanoma cell lines, this being comparable to known anti-melanoma drugs (Supplementary Fig

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