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In patients with PF, the progression of fibrosis is believed to be influenced by three primary factors: excessive epithelial damage caused by inhaled pollutants, senescence, and genetic susceptibility [32]

Masharani UB, Becker J

Then, cells were incubated with 5 M of MitoSOX TM Red dye in PBS with 0.5% serum at 37 C with 5% CO 2 for 30 min before being assessed in a cytoFLEX cytometer (Beckman Coulter)

The rate does slow down, but the glucagon-mediated energy expenditure component means the deceleration may be less pronounced than with tirzepatide