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(download XLSX Classification List of Druggable Genes by Finan et al

However, the enzymatic activity and transcript abundance of glutathione reductases, which convert GSSG back to GSH, did not change significantly in infested resistant plants

Furthermore, decreased Glu transporter expression leads to Glu accumulation outside nerve cells, resulting in the inhibition of the system xc pathway

Potentially, this calcium dyshomeostasis induces mitochondrial dysfunction and bioenergetic deficits, ultimately contributing to axonal degeneration 37