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The activity of SapM towards the phosphodiester substrates bis- p -nitrophenyl phosphate (Bis p NPP) and adenosine 3,5-cyclic monophosphate (c-AMP), typical substrates of phosphodiesterases 36,37 , was less than 5% with respect to p NPP hydrolisis

This may sound like a lot of biochemistry, but the big question is why is the methylation process so important