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By pumping the accumulated, unbound cytosolic catecholamines backward across the plasma membrane and safely into the extracellular synaptic space, the neuron is able to maintain its free cytoplasmic neurotransmitter levels below toxic thresholds , directly protecting itself from oxidative cell death and preserving neuronal viability (Underhill et al., 2021)

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Moreover, increased serotonin (5-HT) levels combined with selective inhibitors of serotonin re-uptake reduces A in the brain interstitial fluid in a mouse model of AD

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