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For example, we showed that the incorporation of 2 H -azirine and -nitrostyrene electrophiles into ligands targeting EGFR L858R/T790M/C797S and BRD4 resulted in potent degraders that recruit NEDD4 and TRIM28 48,49 , respectively, leading to proteasome-dependent protein degradation

However, the residual CD38 low/- NK population displays a high proliferative potential and functional activity

Mol Cell Biochem 266(12):3756

Tube formation was quantified as described previously (8)

Thus, iron accumulation and metabolism disorder after TBI may lead to secondary axonal injury and cognitive dysfunction through inducing oligodendrocyte apoptosis