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Moreover, also the core clock component BMAL1 has been reported to bind to p53 promoter, thereby transcriptionally triggering the downstream tumor suppressor pathway 37

Inflammation can also cause disease, due to damage of healthy tissue

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One clue comes from the observation that activation of murine CD8 + T cells results in l-2HG accumulation, which leads to increased expression of CD62L, a selectin that permits lymph node recirculation, thus dictating cellular migration (125)