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10.1038/s41371-021-00625-1 133 Scanavini-FilhoM

Response 1 is the primary therapeutic effect, the magnitude of which increases with dose from sub-therapeutic, through therapeutic to potentially toxic

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Moreover, cytokines, including TNF-, IL-6, and IFN-, and the populations of infiltrated F4/80 + /CD86 + macrophages and CD3 + /CD8 + T cells in tumor tissues, were significantly upregulated in mouse serum after PCT treatment, further confirming the robust activation of the immune response (Figs