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Acetylation or succinylation of lysine residue located at position 122 (Lys122) within the electrostatic loop reduces its net charge from + 1 to 0 or 1, respectively, hindering the electrostatic guiding of anionic O 2 towards the active site

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NSD2 overexpression drives multiple myeloma dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome