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doi: 10.1007/s11104-024-06855-9 22 ColombageR.SinghM

Figure 2 - Scheme of the chemical biotransformation process (Phases I, II and III).Source: Although not a portal of entry, the kidney is an organ where xenobiotics are likely to be concentrated during the excretion process and this may explain the high level of xenobiotic-metabolizing enzymes in this tissue

In this assay, GSH is formed from GSSG by GR

GC cells are typically resistant to ferroptosis due to increased expression of ferritin [4] and glutathione peroxidase 4 (GPX4) [5], which promotes tumor growth and contributes to chemoresistance

Bridging these gaps will require the integration of human-relevant models such as ovarian organoids and microphysiological systems, the development of validated biomarkers and potency assays, and the execution of large-scale, well-controlled clinical trials with long-term follow-up