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Chronic persistent hypoxia is recurrent in chronic lung diseases where O 2 levels remain constantly low, while chronic IH is characteristic of obstructive sleep apnea, characterized by an intermittent pattern of episodes of hypoxia and reoxygenation [133]

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However, given the lower intracellular GSH:GSSG ratio after IL-13 stimulation, it is difficult to determine the proportionate role that loss of GSH plays in downstream T2-pathway mRNA/protein expression

Further, it has been proposed that GHK-Cu might support angiogenic and nerve-growth processes via signalling pathways, enhancing cellular communication within research frameworks focused on wound or regeneration models