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doi: 10.1038/cdd.2013.45 143 LiuYShoji-KawataSSumpterRMJr.WeiYGinetVZhangLet al

These findings suggest that TLR4 and RAGE signaling may contribute to distinct stages of dAGEs-induced allergic inflammation: TLR4 drives early barrier disruption and localized inflammation, while RAGE is essential for later-stage immune cell activation and allergen-specific responses