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When DAMPs, such as HMGB1 and ATP, bind to pattern recognition receptors (PRRs) on the surface of DCs (e.g., TLR and NLRP3), they trigger DC maturation, enhance antigen processing and presentation capabilities (86), and promote the secretion of proinflammatory factors such as IL-12 and TNF-, as well as CCR7-mediated lymph node homing

doi: 10.1016/j.aninu.2017.06.007 47

2a, top) and negligible staining for the apoptosis marker cleaved caspase 3 (Extended Data Fig

In my practice, I approach Long COVID the same way I approach other complex chronic conditions, such as Lyme disease, mold-related illness, autoimmune disorders, and chronic fatigue syndrome (ME/CFS)