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Finally, inflammation and endothelial activation leads to a pro-thrombotic phenotype due to the upregulation of components of the coagulation cascade including tissue factor (TF) (Sohn et al., 2005)

Chondrocytes are involved in maintaining the integrity of the extracellular matrix and controlling the balance of articular cartilage homeostasis, thereby contributing to the deceleration of OA development (158, 159)