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Furthermore, metabolic reprogramming plays an important role in malignant transformation, the progression of tumors and the resistance to antitumor therapy (18)

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The significant increase of Cu level will promote the catalytic effect of copper-mediated in mitochondria, resulting in the generation of reactive oxygen species (ROS), and excessive ROS will lead to the oxidation of the amino acid side chain of the protein or the break of the peptide chain, which will change the properties of the protein and lead to the loss of various enzyme activities

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