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Instead, functional medicine practitioners often recommend dividing the total daily dose (which can range anywhere from 5 to 15 grams depending on strict clinical guidance) into three or four smaller doses taken throughout the day to maintain highly stable, elevated blood levels

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doi: 10.1016/j.cell.2012.03.042 Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourao A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, ODonnell V, Proneth B, Popowicz GM, Pratt DA, et al