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Ferric iron (Fe 3+ ) is stored within ferritin in the cytoplasm, whereas Fe 2+ for ferroptosis induction is either imported via CD44 from the extracellular compartment [22] or provided via lysosomal ferritin degradation and subsequent reduction [23]

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Readouts include infarct size, vessel density in the ischemic boundary, and markers of myelination and progenitor activity

Androgenic alopecia (AGA), the most common type of hair loss, is characterized by shortened anagen phase or delayed telogen-to-anagen transition and miniaturization of HFs 4

Interestingly, the gut metabolic module aspartate degradation I, which converts L-aspartate to oxaloacetate by aspartate aminotransferase, was elevated in SAD patients and the authors hypothesized that bacterial aspartate aminotransferase enzyme activity may represent a link between gut microbiome function and the tryptophan-kynurenine pathway, a key physiological system in psychiatric disorders (Butler et al., 2023)