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You cannot have a vitamin B12 injection if: You are sensitive to any of the excipients, which are - acetic acid, sodium chloride, sodium hydroxide, and water for injections

"Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance." Diabetologia

Some practitioners recommend twice-daily dosing for acute injuries or severe conditions, splitting the total daily dose into morning and evening injections