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Chin J Cancer Res 33(3):308322

(2024) demonstrated in vitro and in vivo in gemcitabine-resistant cholangiocarcinoma (a biliary cancer model) that CBD induced ROS production (measured by DCFH-DA), ER stress (upregulating CHOP and ATF4), and apoptosis, significantly inhibiting tumor growth in xenografts (Pongking et al

We first performed an iterative Combat normalization with the pcaMethods R package 91 to adjust for batch effects in each data layer (metabolites, lipids, oxylipins, proteins, peptides, and PTMs) for both fresh and stored RBCs