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The methionine cycle consists of 4 substances: Methionine S-adenosylmethionine (SAM) S-adenosyl homocysteine (SAH) Homocysteine The essential task of this cycle is to break down harmful homocysteine and to regenerate it again into the methyl donor S-adenosylmethionine (SAM)

Looney, TJ, Duose, D, Lowman, G, Linch, E, Hajjar, J, Topacio-Hall, D, Xu, M, Zheng, J, Alshawa, A, Tapia, C, Stephen, B, Wang, L , Meric-Bernstam, F, Miller, L, Glavin, A, Lin, L, Gong, J, Conroy, J, Morrison, C, Hyland, FC, Naing, A

10.1016/j.smim.2014.04.003 69

This article aims to elucidate the pathological mechanisms and potential crosstalk mechanisms underlying ferroptosis and mitophagy/CMA in the context of OA

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