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Furthermore, it was demonstrated that the overexpression of PINK1 promoted neuronal activity and protected neuronal integrity ( A substantial body of evidence indicates the presence of mitochondrial fragmentation in neuronal cells in the brains of HD patients, in which the expression levels of the mitochondrial fission/fusion proteins Drp1, Fis1, and Mfn are significantly altered (Shirendeb et al., 2012)

Indeed, increased levels of proinflammatory cytokines, including IL-6, IL-1, IL-17A, and IL-22, are observed in psoriasis, leading to excessive ROS generation from both endogenous and exogenous sources, resulting in increased oxidative stress

When cells were 4060% confluent in 6-well culture plates, the medium was replaced with fresh one 30 min before transfection

The MS acquisition was performed as described 62 with same MS parameters and LC configuration

There are two further points about chlorella to consider