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Tissues such as cardiac and skeletal muscles lack -butyrobetaine hydroxylase, one of the enzymes required for carnitine synthesis, which is why they obtain carnitine from the blood [17,18]

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For example, regulating HSP90 activity improved nerve conduction velocity (NCV) and responses to thermal and mechanical stimuli (both of which are clinically relevant end points), most likely by improving mitochondrial function 44