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Collectively, these results indicate that oxidative stress is a powerful driving force behind antiretroviral-induced toxicity and has important roles in premature-and-accelerated-aging symptoms (Blas-Garcia et al., 2011)

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These effects appear to be more pronounced in aged than in younger subjects (n = 21, age 4875) (Mahdi et al., 2019), and does not depend on efficacy of blood glucose-lowering therapy in T2D patients (n = 16, average age 64) (Mahdi et al., 2018)

Kuip et al

Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle