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PBLs require proper stimulation and IL-2 for proliferation in 2D culture conditions [34]

In a rat experiment examining the effects of a high fat diet on obesity, the use of WS dry leaf powder significantly lessened the expression of pro-inflammatory cytokines both in the body and brain, decreased indicators of reactive gliosis and neuroinflammation, modulated the nuclear factor NF-kappa-B (NF-B) pathway, and lowered cell death (63)

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During adolescence, the body is still growing and going through important hormonal and metabolic changes