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Moreover, addition of DEM, a potent thiol-depleting agent, in cell cultures led to I B degradation in TNF- -treated hGH-producing cells (Figure 4D, lower right), while, as expected, a pattern of stabilised I B was shown in U937-hGH cells with an unmodified thiol level (Figure 4D, upper right)

Previous studies have shown that the microbiota influences Th17 response in the gut [70], and that this intestinal inflammation can enhance pathogen colonization [71]

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We found that 13% of ADC ( N = 515) and 18% of SCC ( N = 504) patients carried transcriptional alterations in ALDH1A1, ALDH1A3 , or ALDH3A1 with a mutually exclusive tendency, suggesting that these genes confer similar functional effects (Fig