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Furthermore, natural compounds such as resveratrol activate SIRT1, suppressing p53-mediated apoptosis and enhancing antioxidant defenses ( + pathway not only alleviates oxidative stress but also improves metabolic disturbances by regulating downstream transcription factors including PGC-1 and FOXO, offering novel therapeutic avenues for DN

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Previous studies referred to both hypo- and hypermethylation, which may arise from the types of techniques used to investigate the DNA modifications [135, 136]