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It has been reported that AC inhibited the proliferation of HT29 human colon cancer cells in a dose-dependent manner with an IC 50 of approximately 50 g/mL, where it exhibited strong anti-metastatic and anti-invasive effects by inhibiting the Rac family small GTPase 1 (Rac-1), hypoxia-inducible factor-1 alpha (HIF-1), and zinc finger E-box-binding homeobox 1 (Zeb-1) pathways (Seyfi et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] [75].Huang S, Tang Y, Peng X, Cai X, Wa Q, Ren D, Li Q, Luo J, Li L, Zou X, Huang S, Acidic extracellular pH promotes prostate cancer bone metastasis by enhancing PC-3 stem cell characteristics, cell invasiveness and VEGF-induced vasculogenesis of BM-EPCs, Oncol