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RESULTS: A total of 85 patients (44 male

Excess ROS can damage all major cellular constituents (DNA, proteins, and lipids) and even lead to cell death, apoptosis, hypertrophy, fibrosis, and contractile dysfunction in the myocardium [8, 11]

While TA-65 administration did not affect the proportions of terminally differentiated CD8 + T-lymphocytes, it led to significant elevations in major lymphocyte subsets and a notable 62% reduction in high-sensitivity C-reactive protein (hsCRP) levels after 12 months compared to placebo