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9 reported for the first time in 1990 that the doseresponse curve obtained by acetylcholine in patients with hypertension was smaller than the curve in normal controls and that the doseresponse curves obtained by sodium nitropreside were similar in the two groups, suggesting that endothelial function, but not smooth muscle function, is selectively impaired in patients with hypertension, a large number of studies have shown that hypertension is associated with endothelial dysfunction